|
|
5,10-methylenetetrahydrofolate + NAD+ <=> 5,10-methenyltetrahydrofolate + NADH
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
MK
|
|
BRENDA:
BR36891
KEGG:
R01218
MetaCyc:
1.5.1.15-RXN
SABIO-RK:
1450
|
|
|
|
5-methyltetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + H+ + NADH
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
MK
|
|
BRENDA:
BR36896-a
KEGG:
R07168
MetaCyc:
1.5.1.20-RXN
SABIO-RK:
9210
|
|
|
|
5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
BMK
|
|
BRENDA:
BR36902;
BS454753
KEGG:
R01220
MetaCyc:
METHYLENETHFDEHYDROG-NADP-RXN
SABIO-RK:
73
|
|
|
|
5,10-methylenetetrahydrofolate + dCMP <=> 7,8-dihydrofolate + 2''-deoxy-5-methylcytidylate
|
2.1.1.45
thymidylate synthase
2.1.1.54
deoxycytidylate C-methyltransferase
|
–
–
|
|
|
BRENDA:
BR40556
KEGG:
R01670
MetaCyc:
DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN
SABIO-RK:
1796
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP <=> dTMP + 7,8-dihydrofolate
|
2.1.1.45
thymidylate synthase
|
–
|
BMK
|
|
BRENDA:
BR43900;
BS319728
KEGG:
R02101
MetaCyc:
THYMIDYLATESYN-RXN
SABIO-RK:
88
|
|
|
|
5-methyltetrahydrofolate + oxidized_ferredoxin <=> 5,10-methylenetetrahydrofolate + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
–
|
BMK
|
|
BRENDA:
BR48613
KEGG:
R01217
MetaCyc:
RXN-5061
|
|
|
|
5-methyltetrahydrofolate + NADP+ <=> 5,10-methylenetetrahydrofolate + NADPH + H+
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
BK
|
|
BRENDA:
BR36896
KEGG:
R01224
SABIO-RK:
1453
|
|
|
|
N,N-dimethylglycine + tetrahydrofolate + flavin <=> sarcosine + 5,10-methylenetetrahydrofolate + reduced_flavodoxin
|
1.5.8.4
dimethylglycine dehydrogenase
|
–
|
K
|
|
BRENDA:
BR36914
KEGG:
R01565
|
|
|
|
L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O
|
2.1.2.1
glycine hydroxymethyltransferase
|
–
|
BMK
|
|
BRENDA:
BR40573
KEGG:
R00945
MetaCyc:
GLYOHMETRANS-RXN
SABIO-RK:
95
|
|
|
|
5,10-methylenetetrahydrofolate + 2-oxoisovalerate + H2O <=> ketopantoate + tetrahydrofolate
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
BMK
|
|
BRENDA:
BR43940
KEGG:
R01226
MetaCyc:
3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN
SABIO-RK:
1455
|
|
|
|
5,10-methylenetetrahydrofolate + D-alanine + H2O <=> 2-methyl-DL-serine + tetrahydrofolate
|
2.1.2.1
glycine hydroxymethyltransferase
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
–
|
K
|
|
BRENDA:
BR43945
KEGG:
R01225
MetaCyc:
D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN
|
|
|
|
dCMP + H2O + 5,10-methylenetetrahydrofolate <=> 2''-deoxy-5-hydroxymethylcytidine_5''-phosphate + tetrahydrofolate
|
2.1.2.8
deoxycytidylate 5-hydroxymethyltransferase
2.1.2.B2
|
–
–
|
K
|
|
BRENDA:
BR43946
KEGG:
R01669
MetaCyc:
2.1.2.8-RXN
|
|
|
|
dUMP + 5,10-methylenetetrahydrofolate + NADPH + H+ <=> dTMP + tetrahydrofolate + NADP+
|
1.5.1.3
dihydrofolate reductase
2.1.1.148
thymidylate synthase (FAD)
|
–
–
|
MK
|
|
BRENDA:
BR47450
KEGG:
R06613
MetaCyc:
RXN-8850
SABIO-RK:
7840
|
|
|
|
sesamin + tetrahydrofolate <=> (+)-demethylpiperitol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BR52315
KEGG:
R11955
MetaCyc:
RXN-18465
|
|
|
|
(+)-demethylpiperitol + tetrahydrofolate <=> (+)-didemethylpinoresinol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BR52316
KEGG:
R11956
MetaCyc:
RXN-18466
|
|
|
|
5,10-methylenetetrahydrofolate + tRNA_UpsiC + FADH2 <=> tetrahydrofolate + tRNA_TpsiC + FAD
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BS319868
KEGG:
R03704
|
|
|
|
S-aminomethyldihydrolipoylprotein + tetrahydrofolate <=> dihydrolipoylprotein + 5,10-methylenetetrahydrofolate + NH3
|
2.1.2.10
aminomethyltransferase
|
–
|
K
|
|
BRENDA:
BS320028
KEGG:
R04125
|
|
|
|
formaldehyde + tetrahydrofolate <=> 5,10-methylenetetrahydrofolate + H2O
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
M
|
|
BRENDA:
BS320035
KEGG:
R09093
MetaCyc:
RXN-2881
|
|
|
|
5,10-methylenetetrahydrofolate + tRNA_UpsiC + NADH <=> tetrahydrofolate + tRNA_TpsiC + NAD+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BS420099
KEGG:
R12548
|
|
|
|
glycine + tetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
|
1.4.1.f
1.4.4.2
glycine dehydrogenase (aminomethyl-transferring)
1.8.1.4
dihydrolipoyl dehydrogenase
2.1.2.10
aminomethyltransferase
|
–
–
–
–
|
MK
|
|
KEGG:
R01221
MetaCyc:
GCVMULTI-RXN
SABIO-RK:
1451
|
|
|
|
D-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O
|
2.1.2.1
glycine hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS409177
SABIO-RK:
15181
|
|
|
|
5,10-methylenetetrahydrofolate + uracil54_in_tRNA + NADPH + H+ <=> tetrahydrofolate + 5-methyluracil54_in_tRNA + NADP+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
MetaCyc:
2.1.1.74-RXN
|
|
|
|
5,10-methylenetetrahydrofolate + uracil54_in_tRNA + NADH + H+ <=> tetrahydrofolate + 5-methyluracil54_in_tRNA + NAD+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
MetaCyc:
2.1.1.74-RXN_WOP
|
|
|
|
N,N-dimethylglycine + tetrahydrofolate + oxidized_electron_transfer_flavoprotein + H+ <=> sarcosine + 5,10-methylenetetrahydrofolate + reduced_flavodoxin
|
1.5.8.4
dimethylglycine dehydrogenase
|
–
|
M
|
|
MetaCyc:
DIMETHYLGLYCINE-DEHYDROGENASE-RXN
|
|
|
|
[glycine-cleavage_complex_H_protein]_N6-aminomethyldihydrolipoyl-L-lysine + tetrahydrofolate <=> [glycine-cleavage_complex_H_protein]_N6-dihydrolipoyl-L-lysine + 5,10-methylenetetrahydrofolate + NH3
|
2.1.2.10
aminomethyltransferase
|
–
|
M
|
|
MetaCyc:
GCVT-RXN
|
|
|
|
CMP + 5,10-methylenetetrahydrofolate + H2O <=> 5-hydroxymethylcytidine_5''-phosphate + tetrahydrofolate
|
2.1.2
|
–
|
M
|
|
MetaCyc:
RXN-15911
|
|
|
|
uracil_in_tRNA + GTP + taurine + H2O + 5,10-methylenetetrahydrofolate + acceptor <=> 5-taurinomethyluridine_in_tRNA + GDP + phosphate + 7,8-dihydrofolate + H+ + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-16822
|
|
|
|
2-thiouridine34_in_tRNA + GTP + 5,10-methylenetetrahydrofolate + glycine + H2O + acceptor <=> 5-carboxymethylaminomethyl-2-thiouridine34_in_tRNA + GDP + phosphate + 7,8-dihydrofolate + H+ + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-18710
|
|
|
|
5-methyltetrahydrofolate + NAD+ + reduced_ferredoxin_[iron-sulfur]_cluster <=> 5,10-methylenetetrahydrofolate + oxidized_ferredoxin + NADH
|
1.5.1.M4
|
–
|
M
|
|
MetaCyc:
RXN-21797
|
|
|
|
5,10-methylenetetrahydrofolate + L-glutamate + ATP <=> 5,10-methylenetetrahydrofolate + ADP + phosphate
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
M
|
|
MetaCyc:
RXN0-2921
|
|
|
|
tRNA_uridine34 + GTP + 5,10-methylenetetrahydrofolate + glycine + H2O + acceptor <=> 5-carboxymethylaminomethyluridine34_in_tRNA + GDP + phosphate + 7,8-dihydrofolate + H+ + reduced_acceptor
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN0-7068
|
|
|
|
2-thiouridine34_in_tRNA + 5,10-methylenetetrahydrofolate + NH3 + GTP + H2O <=> 5-aminomethyl-2-thiouridine34_in_tRNA + 7,8-dihydrofolate + GDP + phosphate
|
not assigned
|
–
|
|
|
MetaCyc:
RXN0-7083
|
|
|
|
ATPgammaS + 5-formyltetrahydrofolate <=> ADPbetaS + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS646
|
|
|
|
ara-ATP + 5-formyltetrahydrofolate <=> araADP + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS645
|
|
|
|
dATP + 5-formyltetrahydrofolate <=> dADP + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS643
|
|
|
|
dTTP + 5-formyltetrahydrofolate <=> dTDP + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS644
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP + FADH2 + O2 <=> dTMP + tetrahydrofolate + FAD + H2O2
|
2.1.1.148
thymidylate synthase (FAD)
|
–
|
|
|
BRENDA:
BS398698
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP + FADH2 <=> dTMP + tetrahydrofolate + FAD
|
2.1.1.148
thymidylate synthase (FAD)
|
–
|
B
|
|
BRENDA:
BS354165
|
|
|
|
5,10-methylenetetrahydrofolate + uracil54_in_tRNA + FADH2 <=> tetrahydrofolate + 5-methyluracil54_in_tRNA + FAD
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BS455098
|
|
|
|
5,10-methylenetetrahydrofolate + FADH2 <=> 5-methyltetrahydrofolate + FAD
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
–
|
|
|
BRENDA:
BS370225
|
|
|
|
5,10-methylenetetrahydrofolate + FADH2 <=> 5,10-methylenetetrahydrofolate + FAD
|
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS375950
|
|
|
|
5,10-methenyltetrahydrofolate + FADH2 <=> 5,10-methylenetetrahydrofolate + FAD
|
1.5.8.4
dimethylglycine dehydrogenase
|
–
|
|
|
BRENDA:
BS370811
|
|
|
|
5,10-methylenetetrahydrofolate + dCTP <=> 7,8-dihydrofolate + deoxy-5-methylcytidine_5''-triphosphate
|
2.1.1.54
deoxycytidylate C-methyltransferase
|
–
|
|
|
BRENDA:
BS289537
|
|
|
|
5,10-methylenetetrahydrofolate + uridine_5''-phosphate <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS319736
|
|
|
|
5,10-methylenetetrahydrofolate + tRNA_UpsiC + FADH2 <=> tetrahydrofolate + tRNA_TpsiC + FAD+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BS387558
|
|
|
|
S-aminomethyldihydrolipoylprotein + tetrahydrofolate <=> enzyme_N6-(dihydrolipoyl)lysine + 5,10-methylenetetrahydrofolate + NH3
|
2.1.2.10
aminomethyltransferase
|
–
|
|
|
BRENDA:
BR43939
|
|
|
|
tetrahydrofolate + 2-methyl-L-serine <=> 5,10-methylenetetrahydrofolate + D-alanine + H2O
|
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS320080
|
|
|
|
ITP + 5-formyltetrahydrofolate <=> IDP + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS642
|
|
|
|
5,10-methylenetetrahydrofolate + reduced_ferredoxin <=> 5-methyltetrahydrofolate + Ferredoxin
|
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS375953
|
|
|
|
(+)-episesamin + tetrahydrofolate <=> 4-[(1S,3aR,4R,6aR)-4-(2H-1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS442630
|
|
|
|
(-)-asarinin + tetrahydrofolate <=> 4-[(1S,3aS,4R,6aS)-4-(2H-1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 4,4''-[(1R,3aS,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]di(benzene-1,2-diol) + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS442632
|
|
|
|
(+)-sesaminol + tetrahydrofolate <=> 4-[(1S,3aR,4S,6aR)-4-(6-hydroxy-2H-1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 5-[(1S,3aR,4S,6aR)-4-(3,4-dihydroxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2,4-triol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS443901
|
|
|
|
(+)-sesamolin + tetrahydrofolate <=> 4-[(1S,3aR,4R,6aR)-4-[(2H-1,3-benzodioxol-5-yl)oxy]tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 4-[[(1R,3aR,4S,6aR)-4-(2H-1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]oxy]benzene-1,2-diol + 4-[(1S,3aR,4R,6aR)-4-(3,4-dihydroxyphenoxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS442631
|
|
|
|
piperine + tetrahydrofolate <=> (2E,4E)-5-(3,4-dihydroxyphenyl)-1-(piperidin-1-yl)penta-2,4-dien-1-one + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS443852
|
|
|
|
5-methyltetrahydrofolate + oxidized_menadione <=> 5,10-methylenetetrahydrofolate + menadiol
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
|
BRENDA:
BS259231
|
|
|
|
5-methyltetrahydropteroylmonoglutamate + 5,10-methylenetetrahydropteroylhexaglutamate <=> 5,10-methylenetetrahydrofolate + 5-methyltetrahydropteroylhexaglutamate
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
|
BRENDA:
BS259233
|
|
|
|
tetrahydrofolate + hydroxymethylserine <=> 5,10-methylenetetrahydrofolate + D-serine + H2O
|
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS320082
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP <=> tetrahydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS375949
|
|
|
|
5-methyltetrahydrofolate + rubredoxin <=> 5,10-methylenetetrahydrofolate + reduced_rubredoxin
|
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS376004
|
|
|
|
5-methyltetrahydrofolate + menadione <=> 5,10-methylenetetrahydrofolate + reduced_menadiol
|
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS376003
|
|
|
|
tetrahydrofolate + 2-ethyl-DL-serine <=> 5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O
|
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS451913
|
|
|
|
tetrahydrofolate + (-)-ethylserine <=> 5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O
|
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS320081
|
|
|
|
GTP + 5-formyltetrahydrofolate <=> GDP + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS641
|
|
|
|
GTP + 5,10-methylenetetrahydrofolate + L-glutamate <=> GDP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS477
|
|
|
|
dATP + 5,10-methylenetetrahydrofolate + L-glutamate <=> dADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS476
|
|
|
|
ITP + 5,10-methylenetetrahydrofolate + L-glutamate <=> IDP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS478
|
|
|
|
UTP + 5,10-methylenetetrahydrofolate + L-glutamate <=> UDP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS479
|
|
|
|
5,10-methylenetetrahydrofolate + NAD+ <=> 5,10-methenyltetrahydropteroylglutamate + NADH + H+
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
|
|
BRENDA:
BS455099
|
|
|
|
5-methyltetrahydrofolate + Oxidized_benzyl_viologen <=> 5,10-methylenetetrahydrofolate + reduced_benzyl_viologen
|
1.5.7.1
methylenetetrahydrofolate reductase (ferredoxin)
|
–
|
|
|
BRENDA:
BS376001
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP + FMNH2 <=> dTMP + tetrahydrofolate + FMN
|
2.1.1.148
thymidylate synthase (FAD)
|
–
|
|
|
BRENDA:
BS354166
|
|
|
|
CTP + 5-formyltetrahydrofolate <=> CDP + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS639
|
|
|
|
5,10-methylenetetrahydrofolate + CTP <=> 7,8-dihydrofolate + 5-methylcytidine_5''-triphosphate
|
2.1.1.54
deoxycytidylate C-methyltransferase
|
–
|
|
|
BRENDA:
BS289539
|
|
|
|
5,10-methylenetetrahydrofolate + uracil54_in_tRNA + NADPH + H+ <=> tetrahydrofolate + 5-methyluracil54_in_tRNA + NADP+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BR43916
|
|
|
|
5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydropteroylglutamate + NADPH + H+
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
|
|
BRENDA:
BS455100
|
|
|
|
UTP + 5-formyltetrahydrofolate <=> UDP + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS640
|
|
|
|
5,10-methylenetetrahydrofolate + acceptor <=> 5-methyltetrahydrofolate + reduced_acceptor
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
|
BRENDA:
BS395977
|
|
|
|
5,10-methylenetetrahydrofolate + reduced_acceptor <=> 5-methyltetrahydrofolate + oxidized_acceptor
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
|
BRENDA:
BS287640
|
|
|
|
ATP + 5,10-methylenetetrahydrofolate + L-glutamate <=> ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS453724
|
|
|
|
ATP + 5,10-methylenetetrahydrofolate + L-glutamate <=> ADP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS453738
|
|
|
|
ATP + 5-formyltetrahydrofolate <=> ADP + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
B
|
|
BRENDA:
BS638
|
|
|
|
5,10-methenyltetrahydrofolate + reduced_N,N-dimethylglycine <=> 5,10-methylenetetrahydrofolate + oxidized_N,N-dimethylglycine
|
1.5.3.10
dimethylglycine oxidase
|
–
|
|
|
BRENDA:
BS372117
|
|
|
|
5,10-methylenetetrahydrofolate + 2''-deoxycytidine_5''-monophosphate <=> 7,8-dihydrofolate + CMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS319742
|
|
|
|
5,10-methylenetetrahydrofolate + CMP <=> 7,8-dihydrofolate + 5-methylcytidylate
|
2.1.1.54
deoxycytidylate C-methyltransferase
|
–
|
|
|
BRENDA:
BS289538
|
|
|
|
5,10-methylenetetrahydrofolate + H2O + CMP <=> tetrahydrofolate + 5-hydroxymethylcytidylate
|
2.1.2.B2
|
–
|
|
|
BRENDA:
BR51681
|
|
|
|
5,10-methylenetetrahydrofolate + H2O + CMP <=> tetrahydrofolate + 5-hydroxymethyl-CMP
|
2.1.2.B2
|
–
|
|
|
BRENDA:
BS454201
|
|
|
|
5-methyltetrahydrofolate + menadione <=> menadiol + 5,10-methylenetetrahydrofolate
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
|
|
SABIO-RK:
12848
|
|
|
|
5,10-methylenetetrahydrofolate + H2O + 2-oxobutyrate <=> 4-Hydroxy-3-methyl-2-oxobutanoic_acid + tetrahydrofolate
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
|
|
SABIO-RK:
14653
|
|
|
|
3-methyl-2-oxopentanoate + H2O + 5,10-methylenetetrahydrofolate <=> 3-(Hydroxymethyl)-3-methyl-2-oxopentanoic_acid + tetrahydrofolate
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
|
|
SABIO-RK:
14655
|
|